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Genetics of Klinefelters Eckert

Page history last edited by Katlyn Decker 14 years ago

Genetics

 

Klinefelters Eckert

Rehabilitation for Klinefelters or Cures

 

Klinefelters syndrome is a genetic condition caused by an anomaly on sex chromosomes. Normal males have one X chromosome and one Y chromosome. Klinefelters males have one extra X chromosome (47,XXY).  The extra X chromosome interferes with the male sexual developement. It reduces the level of testosterone and prevents the testes from functioning normally.

 

 

Figure 1 [1]

 

In figure 1 there is a disfunction in the X chromosome. Even the smallest abnormalities can cause illness or disease. Figure 1 only occurs in males.[2]This genetic disorder is caused by an insertion mutation. And another X chromosome is added to the X and Y existing!

 

 [3]

 

This genetic disorder is typically caused by what is called a nondisjunction. If a pair of sex chrosomomes fails to separate during the formation of an egg (or sperm), this is referred to as non disjunction. That egg unites with a normal sperm to form an embryo, that embryo may end up with three copies of the sex chromosomes (XXY) instead of the normal two (XY). This explains that Klinefelter's syndrome is not hereditary. There is not Punnett Square that can predict if the baby will have the disorder.[4]

 

 

 

 

 

Footnotes

  1. http://www.tokyo-med.ac.jp/genet/picts/xo&xxy.jpg
  2. http://www.freemd.com/klinefelters-syndrome/genetics.htm
  3. http://learn.genetics.utah.edu/content/disorders/whataregd/klinefelter/
  4. http://learn.genetics.utah.edu/content/disorders/whataregd/klinefelter/

Comments (2)

jgeckert@avon-schools.org said

at 8:41 pm on Jan 7, 2010

You've got a good start on this. Keep up the good work. Your group needs to talk a little more about who is doing what. Semi and I did some research this afternoon, but she was a little confused on exactly what part she was doing. I'll talk to your group tomorrow about it. Mrs. Eckert

jgeckert@avon-schools.org said

at 9:21 pm on Jan 12, 2010

Good descriptions of your diagrams. Maybe you could have a sentence explaining that is can be both a sex chromosome disorder as well as a recessive disorder if this is the case. I really thought it was just a nondisjunction problem. This site http://learn.genetics.utah.edu/content/disorders/whataregd/klinefelter/ explains how the chromosome problem happens in pretty simple terms.

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