Angelman Syndrome (archaically known as “Happy Puppet Syndrome”), is a neurological disorder caused by an ineffective gene on the maternal copy of chromosome 15. This gene is rendered ineffective via a mutation, deletion, or inactivation. Characteristics of AS include: developmental delay, lack of speech, seizures, walking and balancing disorders, and an unusually happy demeanor.
History of Angelman Syndrome Per. 2
Chromosome 15 Per. 2
Coping with AS Per. 2
Supporting organizations and research Per. 2
Comments (9)
rryoung@... said
at 9:28 am on Oct 29, 2009
Footnote the intro information..
Bradley Vivace said
at 9:22 am on Nov 4, 2009
The genetics page is wonderful. The location of the disorder and the pictures of those who have inherited Angelman's syndrome are really helpful in understanding the disease.
Jamie Milligan said
at 3:11 pm on Nov 4, 2009
You have a lot of really good information here, and also I love the videos you've put up as well.
Mariah Jones said
at 10:45 pm on Nov 4, 2009
I freally liked your genetcis page. I actually understood most of it. The diagrams defintely helped. I also liked how you went into detail about how the Angelman Syndrome got it's name. I thought it was very organized.
Michael Burns said
at 9:02 am on Nov 5, 2009
The genetics page is really good. It includes most of the information required overall for the project. It is easier to understand using this method.
Cara Maher said
at 9:41 am on Nov 5, 2009
It was interesting to know that one deletion on the maternal chromosome 15 causes Angelman Syndome, but the same deletion on the paternal chromosome 15 cause another disorder all together.
Michael Burns said
at 9:46 am on Nov 5, 2009
I have a blonde aunt who has seizures, but she has no developemental problems. She is really clumsy though. I'm glad that they're happy all the time, I think that would help coping with it.
Chelsea Johnson said
at 9:50 am on Nov 5, 2009
The symptoms for this disease seem like a strange mix. A little more on how they are related would have been nice. The fact that people with AS are generally happy is a little confusing to me. However, parents of children with AS must be glad that their child leads a happy life, rather than a painful life. From what I saw, parents of people with AS consider their children a blessing, not a burden, which is nice.
Leigh Anderson said
at 11:41 am on Nov 5, 2009
I really liked the genetic background you have on this disease. I felt it connected the things we have been learning in class, like gene loci or the types of mutations, in this case a deletion, to a more in depth view of Angelman Syndrome.
I wish you would have given more details about the characterisitics and symptoms of this disease. I think I would have been able to understand the other pages you have a little more.
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